System for fighting giants?

Does any know of/recommend any RPG system, as a whole, or has a sub-system that is robust on making fights against giants (or overly large-sized monsters) more than just simply cutting down a hitpoints monument? Something that handles attacking specifically large body parts (and its effects), taking evasive actions to prevent large sweeping attacks (or getting crushed underfoot), and movement to different body areas?
Something that sounds like it was inspired by Attack on Titan or Shadow of the Colossus would be the ideal I would be looking for, but willing to look at something a little broader or has a different approach. I’m not looking for suggestions on rules-hacking to perform the same.

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